Continued
Procedure
I found this page that gives dosages, for activators at least
http://herbpedia.wikidot.com/oilahuasca-activators
Procedure, in plain English:
Pepper would be made into a tea. Solids filtered out.
Then you would get some Anise Oil, B9 or Valerian Root (of Chinese Origin)
So that is your Pepperidine, and you activators. Now you need your Enzyme Inhibitors. You can add L-Lysine, but it is not necessary.
Vanilla and Cinnamon work, pick one or both. You also need the Aldehyde structure from one of these.
Next. German Chamomile, Cayenne Pepper Capsules or Tangerine Skin extract/capsules
Then
Almond extract, Anise Oil (if you already had it), Cinnamon, Lemon peel oil, Lime peel oil, or a cigarette or nicotine gum if you can't find anything else.
Then
CBD, Echinacea Purea, Pomegranate, Pummelo, or Calamus Oil.
Then
Clove oil, Catechin, Dill seed Oil or Goldenseal.
Then Kudzu or Glycerin or Caffeine
Not all of these things are neccisarry, but if you do 1 thing in each list, you should get very strong effects from whatever you take.
The best thing to take is Sweet Basil Extract, in it's pure form, it is known as Methyl Chavicol.
Take all that other stuff like 30 minutes to an hour before the Basil Extract, and redose the B9, Anise or Valerian root to keep the effects going without taking more.
Science
Graviola- 5-HT1a Agonist
Black Cohosh- 5-HT1A, 5-HT1D & 5-HT7 Binding
C. Foetida L.- 5-HT1A Agonist
Yokukansan- 5-HT1A Agonist
DMT hits all of these, and can be found in tons of plants.
Black Cohosh- 5-HT1D
maybe Rhodiola rosea, Albizia lebbeck & Albizia julibrissin.
5-HT1 Receptor Agonists:
Turmeric, Ginger, Ginko Bilboa, Lemon Essential Oil, Rauwolfia, Valerian, Yohimbe
Elmicin & Myristicin (in Nutmeg)- 5-HT2A Agonist
Estragole (in Sweet Basil)- 5-HT2A Agonist
Safrole (in Sassafras)- 5-HT2A Agonist
Cinnamon Bark- CYP2A6 & CYP2E1 Inhibitor (It will deplete your liver's Glutithione) Taken 1 Hour before Allybenzene,
Clove Leaf- CYP2C9, CYP3A4, CYP1A1 & CYP1B1 Inhibitor
German Chamomile- CYP1A2 Inhibitor (Caffeine may also do this)
GoldenSseal & Echinacea purpurea very effectively do the same thing.
Black seed oil, 50% EGCG, Valerian root oil, Pomegranate, Vitamin B9, 40% Ellagic extract, Rooibos 20% Gallic acid extract, Rutin, B3 & Kudzu
AllylBenzenes
Anethole, Apiol, Asarone, Carpacin, Chavibetol, Chavicol, Dillapiole, Eugenol, Isoeugenol, Isosafrole, Methyl Eugenol, Methyl Isoeugenol,
since Cinnamon is a Phenylpropanoid, and Phenylpropanoids are made from Phenelalamine, and people who took Phenelalamine claim to get better results. I decided to post a list of Phenylpropanoids also.
Caffeyl Alcohol, Cinnamaldehyde, Cinnamyl alcohol, alpha-Cyno-4-hydroxycinnamic acid, Ethyl Cinnamate, Lignin, 2,4-Methlenedioxypropiophenone, Neoflavonoids, Nordihydroguaiaretic acid, Phenylpropanoic acid, Phloretic acid, Rhododendrin & Suberin.
Star Anise Extract or B9 for CYP2C9 Induction
NMDA Receptor Plants:
Uncaria Rhynchophyllia
Psychotria Colorata
Huperzia Serrata
Most important things:
CYP2C9 Induction
Alcohol Dehydrogenase Induction
Aldehyde Dehydrogenase Inhibition
Piperidine and or Dimethylamine Supplementation
Methyl from foods
Exercise or compounds that produce effects like exercise
Less important, but still factors:
SSAO Inhibition (Caffeine, Phenethylamine, Phenelalamine, Tryptamine)
MAO-A Induction
MAO-B Induction
NDMA Antagonism
Prolactin Inhibition
Hungarian Parsley Seed is a better source of Myristicin than Nutmeg. The effects of it when activated properly are said to be like Mescaline and MDMA together. The P450 Enzymes CYP1A2 & CYP3A4 are what break this down and need to be inhibited. CYP2D6 could also play a big role.
Elmicin is something you either need Chromotography type knowledge to get, or you have to buy it in small quantities. When activated properly it is like Mescaline, when activated wrong it is like Melatonin (sleepy). CYP1A1, CYP1B1, CYP1A2, CYP2A6, CYP2C9, CYP2A6, CYP2C9 & CYP2E1 are what are needed to be inhibited to activate this. CYP2D6 could also play an important role.
Safrole is like MDMA when activated properly and like Melatonin when not. CYP2A6, CYP2C9, and CYP2E1 are most important for this. CYP2D6 could also be important.
Methyl Chavicol when activated properly is like a light speedy LSD, when activated wrong it is said to be almost like Marijuana. CYP1A2 and CYP2A6 inhibit it, and CYP2D6 could also be important.
If the CYP2D6 Enzyme is inhibited with all the others, these are possibly visually hallucinogenic Oilahuascas. And the Methyl Chavicol doesn't build a tolerance (the others do) it actually gets stronger for you every time you use it, or you can use less.
Several allylbenzenes have been proven to form up to 3 alkaloid metabolites after ingestion by several animals.[2][3] They do not form amphetamines in vivo as has been speculated in the past. The alkaloids detected in animal urine are tertiary aminopropiophenones of 3 possible subtypes: dimethylamines, piperidines, and pyrrolidines.[1][2][3][4]
The allylbenzene elemicin has been proven to form all 3 different alkaloid metabolites after ingestion in animals by analyzing urine using gas-liquid chromatography and chemical ionization mass spectrometry.[1]
Safrole is also proven to form all three alkaloid metabolites after ingestion.[2]
Myristicin appears to only form piperidines and pyrrolidines. Dimethylamines of myristicin have not been detected.[3]
Allylbenzene, from which all allylbenzenes are derived, forms piperidine and dimethylamine alkaloids.[4]
Propenylbenzene and its derivatives (asarone, anethole, etc.) do not form alkaloid metabolites.[4]
Here is how it works
CYP Enzymes (Drug Metabolism, etc)
Induction and Inhibition (Anti-Oxidants, etc)
All inhibitors of oxidative 17bHSD2 will prevent activation of allylbenzenes. This enzyme must be induced, not inhibited. It's the single most important enzyme to induce. If oxidative 17bHSD2 is not functioning, allylbenzenes cannot produce psychedelic activity. Naringenin also potently inhibits 17bHSD2. Grapefruit contains large amounts of naringenin, and also prevents the psychedelic action of allylbenzenes if taken before allylbenzenes. Inhibition lasts approximately 4-8 hours.
Oilahuasca Diet
Here's a list of all known 17bHSD2 inhibitors that should be avoided 4-8 hours prior to using allylbenzenes:
•Quercetin and all food or supplements containing large amounts of it.
•Apples (0.0263% quercetin)[6]
•Cabbage (0.01% quercetin)[6]
•Cranberry (0.025% quercetin)[6]
•Evening-Primrose (20% quercetin)[6]
•Galangin and all food or supplements containing large amounts of it.
•Garlic (0.02% quercetin)[6]
•Grapefruit (contains naringenin, kaempferol, galangin, and quercetin)
•Himalayan Mayapple (1.2% quercetin)[6]
•Kaempferide and all food or supplements containing large amounts of it.
•kaempferol and all foods that contain large amounts it.
•Mayapple (5% quercetin)[6]
•Naringenin and all food or supplements containing large amounts of it.
•Neem (0.1% Quercetin)[6]
•Oats (0.031% Quercetin)[6]
•Onions (4.81% quercetin).[6]
•Orange (4.58% naringenin)[6]
•Tea (10-25 mg/L quercetin, 6.3-17 mg/L kaempferol [7]).[6]
•Tomato (contains kaempferol, naringenin)
•Yuzu (contains naringenin)
Tasting
Sasha used to invent brand new Molecules that had never been recorded before, and then he would taste them to discover their effects.
Here is how tasting works.
He would invent a new Molecule, similar in structure to an existing molecule. And he would use different tests to see what the Molecule looked like, for example he had a machine that could tell him a few things, and if you put bromide on a molecule and it turns to blood colored or white you can tell it has different things attached to it.
Then, he would take this new Molecule, measure out 1µg and eat it.
Then over 3-4 days he would record the effects, if any, using a scale of +, ++, +++ or ++++
And the 3rd or 4th day he would take 5µg
Then 3-4 days later 10µg
Then 3-4 days later 15µg
Until he found the threshold dosage. At which point he would invite others to try it so he could see how it effected different people. Then they would compare the effects to other things they had taken and determine the Structure Activity Relationship (SAR).
The Shulgin Scale
+, ++, +++, ++++ or +1, +2, +3, +4
+1= Tipsy
+2= High/Drunk, etc. But you could still go to the store
+3= If you went in public, people would say "I think that person is on something"
+4= Seeing God
And now people say "Threshold/Weak", "Medium", "Strong" in terms of that moments mental effects or the effects of a dosage, but Shulgin had things like "Museum Doses" where he would take like 10mg of 2C-I so that the Museum would come alive.
I found this page that gives dosages, for activators at least
http://herbpedia.wikidot.com/oilahuasca-activators
Also, Anti-Oxidants have been used like MAOIs in some of these mixtures.
Myristicin Extract, which is made from Nutmeg, can also be used in place of Methyl Chavicol from Basil.
The effects can range from Ecstasy like to Mescaline like, depending if you do it kind of right or all right.
Also, I have not tried this. There is a structure very similar to Propofol in Thyme called Thymol, but it is broken down in the stomach. So it may be possible to use Thyme extract and digest it like Propofol.
And according to Wikipedia
Thymol has been shown to act as a positive allosteric modulator of GABAa in vitro.
For more information look up Oilahuasca, and share any new info or experiences here. This is probably the most through guide about what plants can be used.